posted on 2023-03-31, 00:02authored byYu-Hung Huang, Weidan Peng, Narumi Furuuchi, Jacquelyn Gerhart, Kelly Rhodes, Neelanjan Mukherjee, Masaya Jimbo, Gregory E. Gonye, Jonathan R. Brody, Robert C. Getts, Janet A. Sawicki
Supplementary Fig. S7. A. Principal component analysis (PCA), and B. Hierarchical Clustering (HCL) Analysis showing distinct difference between transcript profile of siCtrl- and siHuR-transfected A2780 cells. C and D. MA plots of gene expression of 163 genes following transfection of A2780 cells with siHuR and with siCtrl. C. 66 genes were significantly down-regulated and 50 genes were significantly up-regulated when HuR was knocked down. D. 37 significantly down-regulated genes (56%) are direct HuR targets (i.e., HuR binds to their mRNA transcript); 31 significantly up-regulated genes (62%) are direct HuR targets.
Funding
Marsha Rivkin Center for Ovarian Cancer Research
Sharpe-Strumia Research Foundation of the Bryn Mawr Hospital