American Association for Cancer Research
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00085472can140787-sup-128629_2_supp_2745955_nf2gm6.png (4.32 MB)

Supplementary Figure S5 from Chemotherapy-Induced miRNA-29c/Catenin-δ Signaling Suppresses Metastasis in Gastric Cancer

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posted on 2023-03-30, 23:49 authored by Yuxuan Wang, Changzheng Liu, Min Luo, Zhengyi Zhang, Jianan Gong, Jingjing Li, Lei You, Lei Dong, Rui Su, Haishuang Lin, Yanni Ma, Fang Wang, Yi Wang, Jie Chen, Junwu Zhang, Hongyan Jia, Yan Kong, Jia Yu

Supplementary Figure S5. The suppressive effect of miR-29c on GC formation.

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ARTICLE ABSTRACT

Chemotherapy has improved the survival of patients with gastric cancer by unknown mechanisms. In this study, we showed that cisplatin and docetaxel used in gastric cancer treatment increase the expression of miRNA-29 (miR-29) family members and decrease the expression of their oncogenic targets, mediating a significant part of the efficacious benefits of these chemotherapeutic agents. In particular, patients with gastric cancer who experienced recurrences after chemotherapy tended to exhibit low levels of miR-29c expression in their tumors, suggesting that miR-29c activation may contribute to the chemotherapeutic efficacy. Enforced expression of miR-29s in gastric cancer cells inhibited cell invasion in vitro and in vivo by directly targeting catenin-δ (CTNND1). Drug treatment suppressed gastric cancer cell invasion by restoring miR-29c–mediated suppression of catenin-δ and RhoA signaling. In parallel, drug treatment also activated several tumor-suppressive miRNAs, thereby decreasing expression of their oncogenic effector targets. Overall, our findings defined a global mechanism for understanding the efficacious effects of cytotoxic chemotherapy in gastric cancer. Cancer Res; 75(7); 1332–44. ©2015 AACR.