posted on 2023-03-31, 19:21authored byLiana B. Guedes, Carlos L. Morais, Fawaz Almutairi, Michael C. Haffner, Qizhi Zheng, John T. Isaacs, Emmanuel S. Antonarakis, Changxue Lu, Harrison Tsai, Jun Luo, Angelo M. De Marzo, Tamara L. Lotan
Correlation of AR protein by IHC and AR-E1 RISH labeling in high grade primary tumors and benign prostate epithelium sampled on needle biopsy (Figure 5). (A) AR IHC quantified as brown/(brown+blue) pixels vs AR-E1 quantification shows a weak but significant correlation among primary tumors. (B) Quantified AR-IHC from (A) is higher in tumor compared to paired benign epithelium. (C) AR-IHC quantified as a modified H-score (see Methods) shows an insignificant correlation with quantified AR-E1 in the same samples. (D) There is a significant trend towards increased AR IHC H-scores in tumor compared to paired benign epithelium.