crc-22-0478-s06.png (3.23 MB)

Supplementary Figure S4 from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway

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posted on 2023-08-18, 14:20 authored by Inyoung Lee, Miriam Doepner, Jillian Weissenrieder, Ariana D. Majer, Sophia Mercado, Angela Estell, Christopher A. Natale, Pamela J. Sung, J. Kevin Foskett, Martin P. Carroll, Todd W. Ridky

Supplementary Figure S4. Colony morphology of human AML cells and normal mononuclear cells (A and B) Brightfield image of colony formation of primary AML cells treated with (A) DMSO and (B) 250nM LNS8801. (C-H) Brightfield image of normal mononuclear cell colony morphologies.

Funding

HHS | NIH | National Cancer Institute (NCI)

History

ARTICLE ABSTRACT

Previous work demonstrated that LNS8801 inhibits cancer via GPER activation, especially in solid tumors. Here we show that LNS8801 inhibits AML via GPER-independent mechanisms that include ROS induction and ER activation.