American Association for Cancer Research
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Supplementary Figure S3 from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway

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posted on 2023-08-18, 14:20 authored by Inyoung Lee, Miriam Doepner, Jillian Weissenrieder, Ariana D. Majer, Sophia Mercado, Angela Estell, Christopher A. Natale, Pamela J. Sung, J. Kevin Foskett, Martin P. Carroll, Todd W. Ridky

Supplementary Figure S3. GPER expression grossly does not correlate with AML outcome and mutation status (A) GPER expression stratified by ELN2017. (B) GPER expression stratified by FLT3-ITD mutation status. (C) GPER expression stratified by different AML fusion proteins. All data were acquired from the BEAT-AML dataset. P-values were calculated via one-way ANOVA multiple comparisons (*p=<0.05, **p=<0.01, ***p=<0.001, ****p=<0.0001).


HHS | NIH | National Cancer Institute (NCI)



Previous work demonstrated that LNS8801 inhibits cancer via GPER activation, especially in solid tumors. Here we show that LNS8801 inhibits AML via GPER-independent mechanisms that include ROS induction and ER activation.