Supplementary Figure S3 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma

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posted on 2023-05-22, 14:20 authored by Ritu Chaudhary, Robbert J.C. Slebos, Leenil C. Noel, Feifei Song, Maria I. Poole, Dirk S. Hoening, Juan C. Hernandez-Prera, Jose R. Conejo-Garcia, Jose A. Guevara-Patino, Xuefeng Wang, Mengyu Xie, Aik Choon Tan, Christine H. Chung

<p>Heatmap of molecular subgroups in MCC18754 (n=48). RNA expression data was z-normalized, each row represents a single gene in the Hypoxia-Immune signature gene list, each column represents a patient sample. Samples were reordered according to its molecular subgroup: Immune (blue), Mixture (black) and Hypoxia (red).</p>

Funding

HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR)

HHS | NIH | National Cancer Institute (NCI)

James and Esther King Biomedical Research Grant

History

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1.
DOI - Is supplement to EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma

ARTICLE ABSTRACT

While the hypoxic and immunosuppressive TME of HNSCC has been well described, comprehensive evaluation of the immune cell components and signaling pathways contributing to immunotherapy resistance has been poorly characterized. We further identified additional molecular determinants and potential therapeutic targets of the hypoxic TME to fully leverage currently available targeted therapies that can be administered with immunotherapy.