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Supplementary Figure 8 from The Splicing Factor PTBP1 Represses TP63 γ Isoform Production in Squamous Cell Carcinoma

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posted on 2023-04-04, 02:04 authored by William Taylor, Stéphane Deschamps, David Reboutier, Luc Paillard, Agnès Méreau, Yann Audic

endogenous TP63 regulation is unaffected in HaCaT cell lines expressing minigenes

Funding

Ligue Contre le Cancer (French League Against Cancer)

History

ARTICLE ABSTRACT

Quantifying TP63γ isoforms in patients’ tumors could allow for the early detection of patients with HNSCC with an early loss in desmosomal gene expression and poor prognostic. The identification of PTBP1 as a transacting factor controlling TP63γ production may allow to control TP63γ expression.

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Keywords

Head, Neck & Oral Cancers Gene Regulation Posttranscriptional and translational control Biomarkers Prognostic biomarkers Biochemistry

Licence

CC BY