Supplementary Figure 7. Effects of progestin, MPA, and Dex on E2-stimulated growth in MCF-7:WS8 cells. from Molecular Modulation of Estrogen-Induced Apoptosis by Synthetic Progestins in Hormone Replacement Therapy: An Insight into the Women's Health Initiative Study

<p>Supplementary Figure 6. MCF-8:WS8 cells were transferred to estrogen-free medium for 3 days. The, cells were loaded in 24-well plates. A. MCF-7:WS8 cells were treated with vehicle, 0.01µM R5020, 1nM E2, and 0.01µM R5020+1nM E2. Cells were harvested after 7 days treatment and DNA was quantified. P<0.05, * compared with control. P<0.001, ** compared with control. B. MCF-7:WS8 cells were treated with vehicle, different concentrations of MPA as indicated, 1nM E2, and different concentrations of MPA+1nM E2. Cells were harvested after 7 days treatment and DNA was quantified. P<0.05, * compared with E2-treated group. P<0.001, ** compared with control. C. MCF-7:WS8 cells were treated with vehicle, different concentrations of Dex as indicated, 1nM E2, and different concentrations of Dex+1nM E2. Cells were harvested after 7 days treatment and DNA was quantified. P<0.05, * compared with E2-treated group. P<0.001, ** compared with control.</p>