American Association for Cancer Research
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Supplementary Figure 5 from Adjuvant Therapy with Oncolytic Adenovirus Delta-24-RGDOX After Intratumoral Adoptive T-cell Therapy Promotes Antigen Spread to Sustain Systemic Antitumor Immunity

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posted on 2023-06-27, 14:20 authored by Hong Jiang, Dong Ho Shin, Yanhua Yi, Xuejun Fan, Joy Gumin, Jiasen He, Andrew G. Gillard, Frederick F. Lang, Candelaria Gomez-Manzano, Juan Fueyo

Expression of CD3 and CD8 on CD45+ leukocytes from B16F10-RFLuc-3 tumors. Delta-24-RGDOX was injected into the s.c. tumors on Days 8, 11 and 14. Leukocytes from the tumors were profiled through flow cytometry on Day 18. RGDOX: Delta-24-RGDOX.

Funding

HHS | NIH | NCI | National Cancer Institute (NCI)

The University Cancer Foundation via the Institution Research Grant program at The University of Texas MD Anderson Cancer Center

the John and Rebekah Harper Fellowship

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ARTICLE ABSTRACT

Adjuvant therapy with oncolytic viruses promotes antigen spread to potentiate localized intratumoral adoptive T-cell therapy with limited TAA targets, leading to sustainable systemic antitumor immunity to overcome tumor relapse.