American Association for Cancer Research
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Supplementary Figure 1: Scatterplots of the associations between BMI (kg/m2) and WC (Fig 1a) and between BMI (kg/m2) and WHR (Fig 1b). from Measured Adiposity in Relation to Head and Neck Cancer Risk in the European Prospective Investigation into Cancer and Nutrition

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posted on 2023-03-31, 14:07 authored by Heather A. Ward, Petra A. Wark, David C. Muller, Annika Steffen, Mattias Johansson, Teresa Norat, Marc J. Gunter, Kim Overvad, Christina C. Dahm, Jytte Halkjær, Anne Tjønneland, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Sylvie Mesrine, Paul Brennan, Heinz Freisling, Kuanrong Li, Rudolf Kaaks, Antonia Trichopoulou, Pagona Lagiou, Salavatore Panico, Sara Grioni, Rosario Tumino, Paolo Vineis, Domenico Palli, Petra H.M. Peeters, H. Bas. Bueno-de-Mesquita, Elisabete Weiderpass, Antonio Agudo, Jose Ramón Quirós, Nerea Larrañaga, Eva Ardanaz, José María Huerta, María-José Sánchez, Göran Laurell, Ingegerd Johansson, Ulla Westin, Peter Wallström, Kathryn E. Bradbury, Nicholas J. Wareham, Kay-Tee Khaw, Clare Pearson, Heiner Boeing, Elio Riboli

Scatterplots of the associations between BMI (kg/m2) and WC (Fig 1a) and between BMI (kg/m2) and WHR (Fig 1b).


European Commission

International Agency for Research on Cancer

Danish Cancer Society

Ligue Contre le Cancer

Institut Gustave Roussy

Mutuelle Générale de l'Education Nationale

Institut National de la Santé et de la Recherche Médicale

German Cancer Aid

German Cancer Research Center

Federal Ministry of Education and Research

Deutsche Krebshilfe

Deutsches Krebsforschungszentrum

Hellenic Health Foundation

Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council

Dutch Ministry of Public Health, Welfare and Sports

Netherlands Cancer Registry

LK Research Funds

Dutch Prevention Funds

Dutch ZON

World Cancer Research Fund

Statistics Netherlands

Nordic Centre of Excellence programme on Food, Nutrition and Health

Health Research Fund

Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, ISCIII RETIC

Swedish Cancer Society

Swedish Research Council and County Councils of Skåne and Västerbotten

Cancer Research UK

Medical Research Council



Background: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer. However, most studies have used self-reported anthropometry which is prone to error.Methods: Among 363,094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cases of head and neck cancer. Head and neck cancer risk was examined in relation to body mass index (BMI) [lean: <22.5 kg/m2, normal weight (reference): 22.5–24.9 kg/m2, overweight 25–29.9 kg/m2, obese: ≥30 kg/m2], waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) using Cox proportional hazards models.Results: Among men, a BMI < 22.5 kg/m2 was associated with higher head and neck cancer risk [HR 1.62; 95% confidence interval (CI), 1.23–2.12)]; BMI was not associated with head and neck cancer among women. WC and WHR were associated with greater risk of head and neck cancer among women (WC per 5 cm: HR, 1.08; 95% CI, 1.02–1.15; WHR per 0.1 unit: HR, 1.64; 95% CI, 1.38–1.93). After stratification by smoking status, the association for WHR was present only among smokers (Pinteraction = 0.004). Among men, WC and WHR were associated with head and neck cancer only upon additional adjustment for BMI (WC per 5 cm: HR 1.16; 95% CI, 1.07–1.26; WHR per 0.1 unit: HR, 1.42; 95% CI, 1.21–1.65).Conclusions: Central adiposity, particularly among women, may have a stronger association with head and neck cancer risk than previously estimated.Impact: Strategies to reduce obesity may beneficially impact head and neck cancer incidence. Cancer Epidemiol Biomarkers Prev; 26(6); 895–904. ©2017 AACR.

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