American Association for Cancer Research

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Supplemental Table S6 from Real-world Validation of TMB and Microsatellite Instability as Predictive Biomarkers of Immune Checkpoint Inhibitor Effectiveness in Advanced Gastroesophageal Cancer

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posted on 2023-04-04, 01:46 authored by Ryon P. Graf, Virginia Fisher, James Creeden, Alexa B. Schrock, Jeffrey S. Ross, Halla Nimeiri, Geoffrey R. Oxnard, Samuel J. Klempner

Summary of TMB ranges per cohort and PD-L1. The median and interquartile range of TMB is shown per group within the cohorts, grouped by PD-L1 status.


AGA Research Foundation (American Gastroenterological Association (AGA) Research Foundation)



Using real-world data, we sought to evaluate robustness of these clinical associations using the same assay platform and biomarker cut-off point used in both clinical trials and pan-tumor CDx approvals for later treatment lines. TMB ≥ 10 robustly identified patients with mEG with more favorable outcomes on ICPI monotherapy versus chemotherapy and suggests this subset of patients could be targeted for further trial development.