American Association for Cancer Research
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Supplemental Figures 1-7, Tables 1-3 from Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles

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posted on 2023-04-04, 01:42 authored by Yitian Xu, Licheng Zhang, Jose Thaiparambil, Sunny Mai, Dimuthu Nuwan Perera, Jilu Zhang, Ping-Ying Pan, Cristian Coarfa, Kenneth Ramos, Shu-Hsia Chen, Randa El-Zein

Supplemental Figure 1, CD45 staining of normal adjacent tissue of 5 AA and 5 CA patients. Supplemental Figure 2, survival curves for CA and AA patients (A), from patients with different smoking histories (B), and CA and AA patients with different smoking histories (C). D, immune population comparisons between patients with different smoking histories without stratification by race. Supplemental Figure 3, survival rate (A) and curves (B) for male and female patients. C, survival curves for male and female CA and AA patients. D, immune population comparisons between male and female patients without stratification by race. Supplemental Figure 4, survival rate (A) and curves (B) patients with different tumor types. C, survival curves for CA and AA patients with different tumor types. D, immune population comparisons between patients with different tumor types without stratification by race. Supplemental Figure 5, immune population comparisons between CA and AA patients after stratifying by tumor type. Supplemental Figure 6, immune population comparisons between patients with different survival status without (A) or with (B) stratification by race. Supplemental Figure 7, immune population comparisons between patients at different disease stages without (A) or with (B) stratification by race. Supplemental Table 1, antibody list. Supplemental Table 2, number of samples processed for IMC evaluation of different tumor sub-types. Supplemental Table 3, number of samples processed for IMC evaluation of different disease stages.

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ARTICLE ABSTRACT

We report biological racial differences among patients with lung cancer where Caucasians present a hot tumor microenvironment compared with cold tumor in AAs. Treatment plans should be customized to maximize therapeutic outcomes.