Supplemental Figure S2 from Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-Low Insertion Peptide Probes In Vivo
posted on 2023-03-31, 19:05authored byCharles W. Kimbrough, Anil Khanal, Matthew Zeiderman, Bigya R. Khanal, Neal C. Burton, Kelly M. McMasters, Selwyn M. Vickers, William E. Grizzle, Lacey R. McNally
Supplemental Figure S2: As the K7-750 probe did not bind to pancreas tumors, deoxy-hemoglobin signal was utilized to denote the location of the pancreas tumors. Orthogonal views of deoxy-hemoglobin signal indicate the location of the pancreatic tumor bed in both S2VP10 and S2013 xenografts. (A) Orthogonal view of deoxy-hemoglobin signal indicating the S2VP10 tumor within the mouse. Mouse shown is the same mouse shown as injected with V7-750 probe in Figure 3. MSOT images of this mouse are also available as a movie clip (Supplement Figure S5). (B) Orthogonal view of deoxy-hemoglobin signal indicating the S2VP10 tumor within the mouse that was injected with K7-750 (mouse shown from Figure 3).