Supplemental Figure 3 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression

Supplemental Figure 3. Integrative analysis of methylation and gene expression. The methylation level for the five most differentially expressed genes (listed at the top of each page), for which also methylation data was available, is shown in Panels A-E for each gene. Chromosomal position of the corresponding gene is shown on the x-axis, and the methylation in percentage is shown on the y-axis. Each star represents one CpG. CpG''s for BB are shown in green, while CpG''s for FB are shown in orange. For both types a LOWESS (Locally Weighted Scatterplot Smoothing) smoother was used to create a "regression line". The boxplot in panel F for each gene presents the normalized gene expression for both samples (BB and FB) for the five previously picked genes. Again, green indicates a BB-sample and orange indicates a FB-sample. Each box visualizes two normalized gene expressions (two replicates).