American Association for Cancer Research
00085472can142732-sup-137953_3_supp_2838665_nssdhs.png (27.81 MB)

Supplemental Figure 3 from Dietary Microbes Modulate Transgenerational Cancer Risk

Download (27.81 MB)
posted on 2023-03-30, 23:51 authored by Theofilos Poutahidis, Bernard J. Varian, Tatiana Levkovich, Jessica R. Lakritz, Sheyla Mirabal, Caitlin Kwok, Yassin M. Ibrahim, Sean M. Kearney, Antonis Chatzigiagkos, Eric J. Alm, Susan E. Erdman

L. reuteri dietary enrichment protects the F1 progeny of NWD-fed mothers from transgenerational cancer. Pulmonary adenocarcinoma, hepatocellular carcinoma and mesenteric lymph node lymphoma in the children of mothers consuming NWD are shown in the left column. Compare with normal lung, liver and mesenteric lymph node histology from mice of similar descend that were also treated with L. reuteri.



Environmental factors are suspected in the increase of obesity and cancer in industrialized countries but are poorly understood. Here, we used animal models to test how future generations may be affected by Westernized diets. We discover long-term consequences of grandmothers' in utero dietary exposures, leading to high rates of obesity and frequent cancers of lung and liver in two subsequent generations of mice. Transgenerational effects were transplantable using diet-associated bacteria communities alone. Consequently, feeding of beneficial microbes was sufficient to lower transgenerational risk for cancer and obesity regardless of diet history. Targeting microbes may be a highly effective population-based approach to lower risk for cancer. Cancer Res; 75(7); 1197–204. ©2015 AACR.