posted on 2023-04-03, 23:01authored byJudah E. Glogauer, Chun X. Sun, Grace Bradley, Marco A.O. Magalhaes
A- Live cell imaging of neutrophil and UMSCC47 co-cultures showing the intimate contact between cancer cells, matrix and neutrophils. The arrows point to neutrophils in close contact with cancer cells and matrix. B- Neutrophil culture showing the neutrophil-mediated matrix degradation. C- Neutrophil and UMSCC47 co-culture showing the dot-like invadopodia-mediated degradation and the neutrophil-mediated degradation. Neutrophils are washed away during fixation and therefore cannot be seen in these images. Cancer cells migrate during the 24h of the experiments and can be seen close to or on top of neutrophil degraded areas. Note that degradation "dots" caused by cancer cells are still visible under the neutrophil-mediated degradation.