posted on 2023-04-03, 16:42authored byLeslie A. Parsels, David Karnak, Joshua D. Parsels, Qiang Zhang, Jonathan Vélez-Padilla, Zachery R. Reichert, Daniel R. Wahl, Jonathan Maybaum, Mark J. O'Connor, Theodore S. Lawrence, Meredith A. Morgan
Supplemental Figure 1: Cytotoxicity by combined WEE1 and PARP inhibition. Supplemental Figure 2: The effects of AZD1775 and olaparib on the radiation-induced G2 checkpoint. Supplemental Figure 3: The effects of AZD1775 and olaparib on RT-mediated γH2AX-staining in lung cancer cells. Supplemental Figure 4: Exogenous nucleosides attenuate AZD1775-induced high-intensity γH2AX staining but do not rescue AZD1775-mediated inhibition of RAD51 focus formation. Supplemental Figure 5: Relative levels of chromatin-bound PARP1 in Calu-6 cells treated with radiation (6 Gy), AZD1775 and either olaparib or veliparib. Supplemental Table 1: The effects of AZD1775 and olaparib on radiosensitization of Calu-6-derived tumor xenografts.