Suppl. Fig. 1: Experimental design. from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake
posted on 2023-03-31, 01:23authored byBastian Zinnhardt, Hayet Pigeon, Benoit Thézé, Thomas Viel, Lydia Wachsmuth, Inga B. Fricke, Sonja Schelhaas, Lisa Honold, Katrin Schwegmann, Stefan Wagner, Andreas Faust, Cornelius Faber, Michael T. Kuhlmann, Sven Hermann, Michael Schäfers, Alexandra Winkeler, Andreas H. Jacobs
Gli36dEGFR cells were implanted. Thereafter, two imaging sequences were conducted: In sequence 1, T2w MRI and PET with [18F]DPA-714 was performed, while [18F]BR-351 PET and [18F]FET PET were conducted at day 13 and 14, respectively. In imaging sequence 2, T2w MRI and [18F]FET PET were conducted at day 12, followed by [18F]BR-351 and [18F]DPA-714 at day 13 and 14, respectively. After the last imaging experiment, mice were sacrificed and the brains immediately harvested for further analysis.
Funding
International Max-Planck Research School – Molecular Biomedicine