posted on 2023-04-03, 15:02authored byStefanie Chan, Praveen Sridhar, Rory Kirchner, Ying Jie Lock, Zach Herbert, Silvia Buonamici, Peter Smith, Judy Lieberman, Fabio Petrocca
Figure S1: Core RNA splicing genes are frequently up-regulated in basal-like TNBC; Figure S2: PRPF8 and PRPF38A knockdown have similar effect based on gene expression; Figure S3: PRPF8 knockdown promotes G2/M arrest and histone-H3 phosphorylation in MB468 cells ;Figure S4: Ribosomal, immune response, cell cycle, mitosis and proteasome transcripts are commonly sensitive to PRPF8 knockdown across different cell lines. ;Figure S5: PRPF8 knockdown disrupts MCL1 splicing across different cell lines. ;Figure S6: MB468 and HCC1187 cells are sensitive to siRNA-mediated SF3B1 knockdown; Figure S7: E7107 suppresses HCC1187 xenograft growth at a well-tolerated dose
Funding
NCI
Boston University/Boston Medical Center Startup Fund