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Figure SF9 from Plexin-B1 Mutation Drives Metastasis in Prostate Cancer Mouse Models

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posted on 2023-04-04, 02:22 authored by Boris Shorning, Neil Trent, David F. Griffiths, Thomas Worzfeld, Stefan Offermanns, Matthew J. Smalley, Magali Williamson

Proliferation and ROCK activation in Ptenfl/flKrasG12V PlxnB1-/- and Ptenfl/flp53fl/fl PlxnB1-/- mice

Funding

prostate cancer research (charity no. 1156027)

History

ARTICLE ABSTRACT

Few therapeutic targets have been identified specifically for preventing locally invasive/oligometastatic prostate cancer from becoming more widely disseminated. Our findings suggest Plexin-B1 signaling, particularly from the clinically relevant P1597L mutant, is such a target.

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Keywords

Oncogenes & Tumor Suppressors Suppressors of metastasis Progression, Invasion & Metastasis Metastasis Genitourinary Cancers Prostate cancer Preclinical Models Animal models of cancer

Licence

CC BY