American Association for Cancer Research
crc-22-0265-s05.pptx (5.54 MB)

Figure S4 from Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells

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posted on 2023-05-25, 14:20 authored by S.M. Rafiqul Islam, Takuya Maeda, Naritaka Tamaoki, Meghan L. Good, Rigel J. Kishton, Biman C. Paria, Zhiya Yu, Marta Bosch-Marce, Nicole M. Bedanova, Chengyu Liu, Michael J. Kruhlak, Nicholas P. Restifo, Raul Vizcardo

Figure S4: Characterization of tumor antigen specific TIL-iPSC clone derived from patient 3784


HHS | NIH | NCI | Cancer Moonshot (Misión contra el Cáncer)

HHS | NIH | NHLBI | NHLBI Division of Intramural Research (DIR)



Reprogramming of TIL into iPSC holds great promise for the future treatment of cancer due to their rejuvenated nature and the retention of tumor-specific TCRs. One limitation is the lack of selective and efficient methods for reprogramming tumor-specific T cells from polyclonal TIL. Here we addressed this limitation and present a method to efficiently reprogram TIL into iPSC colonies carrying diverse tumor antigen reactive TCR recombination.