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Figure S4 from Real-world Validation of TMB and Microsatellite Instability as Predictive Biomarkers of Immune Checkpoint Inhibitor Effectiveness in Advanced Gastroesophageal Cancer
Unadjusted for known treatment assignment imbalances, patients receiving 2nd line ICPI vs. chemotherapy have more favorable outcomes when TMB ≥ 10 but not TMB < 10. Kaplan-Meier curves are unadjusted for imbalances. TTNT is shown by drug class for (A) TMB < 10, and (B) TMB ≥ 10. OS is shown by drug class for (C) TMB < 10, and (D) TMB ≥ 10. X-axis is truncated at 36 months. Overall survival estimates are left truncated (see Methods) with at-risk tables adjusted accordingly. Interaction models can be found in Supplemental Figure 8.