crc-21-0134-s04.png (176.99 kB)

Figure S4 from Impaired Antitumor Immune Response in MYCN-amplified Neuroblastoma Is Associated with Lack of CCL2 Secretion and Poor Dendritic Cell Recruitment

figure

posted on 2023-04-04, 01:42 authored by Jamila Kacher, Olivier Manches, Caroline Aspord, Hervé Sartelet, Laurence Chaperot

Supplementary figure 4 shows flow cytometry gating strategy for cell subsets identification (migration experiments)

Funding

Etablissement Français du Sang (EFS)

History

ARTICLE ABSTRACT

In MYCN-nonamplified neuroblastoma, CCL2 produced by neuroblastoma cells induces the recruitment of antigen-presenting cells (DCs and monocytes/macrophages), allowing infiltration by T cells, in link with CCL19 and CCL22 production, hence favoring immune responses.

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Keywords

Immunology Dendritic cells Immunomodulation Tumor Microenvironment Cytokines and the microenvironment Immune cells and the microenvironment CNS Cancers Neuroblastomas Oncogenes & Tumor Suppressors

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CC BY