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Figure S3 from Combined Treatment with a WNT Inhibitor and the NSAID Sulindac Reduces Colon Adenoma Burden in Mice with Truncated APC

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posted on 2023-04-04, 01:22 authored by Maree C. Faux, Janet Weinstock, Sophia Gogos, Emma Prato, Alexander I. Azimpour, Ryan O'Keefe, Yasmin Cathcart-King, Alexandra L. Garnham, Matthias Ernst, Adele Preaudet, Michael Christie, Tracy L. Putoczki, Michael Buchert, Antony W. Burgess

Histology and immunohistochemical analysis of beta-catenin in adenomas from treated Dclk1Cre/+;Apcfl/fl mice.

Funding

Department of Health | National Health and Medical Research Council (NHMRC)

Ludwig Institute for Cancer Research (LICR)

Walter and Eliza Hall Institute (WEHI)

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ARTICLE ABSTRACT

Colorectal cancer is one of the most common cancers worldwide with limited therapeutic options. APC and other Wnt signaling mutations occur in the majority of colorectal cancers but there are currently no Wnt inhibitors in the clinic. The combination of Wnt pathway inhibition with sulindac provides an opportunity for killing Apc-mutant colon adenoma cells and suggests a strategy for colorectal cancer prevention and new treatments for patients with advanced colorectal cancer.

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Keywords

Gastrointestinal Cancers Colorectal cancer Small Molecule Agents Carcinogenesis Premalignancy Oncogenes & Tumor Suppressors Tumor suppressor genes

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