00085472can163410-sup-175887_3_supp_4130610_ysy0y0.png (6.79 MB)

Figure S2 from Chromatin-Associated Protein SIN3B Prevents Prostate Cancer Progression by Inducing Senescence

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posted on 2023-03-31, 00:44 authored by Anthony J. Bainor, Fang-Ming Deng, Yu Wang, Peng Lee, David J. Cantor, Susan K. Logan, Gregory David

Images of 12-month-old prostates from each genotype before removal from the mouse. Sin3bpc-/- Ptenpc-/- tumors originate from the prostate epithelium as evidenced by their positive staining for both AR and CK18.

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NIH

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Samuel Waxman Cancer Research Foundation

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ARTICLE ABSTRACT

Distinguishing between indolent and aggressive prostate adenocarcinoma remains a priority to accurately identify patients who need therapeutic intervention. SIN3B has been implicated in the initiation of senescence in vitro. Here we show that in a mouse model of prostate cancer, SIN3B provides a barrier to malignant progression. SIN3B was required for PTEN-induced cellular senescence and prevented progression to invasive prostate adenocarcinoma. Furthermore, SIN3B was downregulated in human prostate adenocarcinoma correlating with upregulation of its target genes. Our results suggest a tumor suppressor function for SIN3B that limits prostate adenocarcinoma progression, with potential implications for the use of SIN3B and its target genes as candidate diagnostic markers to distinguish indolent from aggressive disease. Cancer Res; 77(19); 5339–48. ©2017 AACR.

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Keywords

Cell Death And Senescence Cellular aging and senescence Genitourinary Cancers Prostate cancer Preclinical Models Animal models of cancer Progression, Invasion & Metastasis

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