American Association for Cancer Research
00085472can163410-sup-175887_3_supp_4130609_qsq0y0.png (2.92 MB)

Figure S1 from Chromatin-Associated Protein SIN3B Prevents Prostate Cancer Progression by Inducing Senescence

Download (2.92 MB)
posted on 2023-03-31, 00:44 authored by Anthony J. Bainor, Fang-Ming Deng, Yu Wang, Peng Lee, David J. Cantor, Susan K. Logan, Gregory David

Deletion of Sin3b does not impair loss of PTEN-driven AKT activation in the prostate anterior lobe. IHC stainings for SIN3B, PTEN, and pAKT of the anterior lobe of prostates taken from 3-month-old mice of each genotype.




Samuel Waxman Cancer Research Foundation





Distinguishing between indolent and aggressive prostate adenocarcinoma remains a priority to accurately identify patients who need therapeutic intervention. SIN3B has been implicated in the initiation of senescence in vitro. Here we show that in a mouse model of prostate cancer, SIN3B provides a barrier to malignant progression. SIN3B was required for PTEN-induced cellular senescence and prevented progression to invasive prostate adenocarcinoma. Furthermore, SIN3B was downregulated in human prostate adenocarcinoma correlating with upregulation of its target genes. Our results suggest a tumor suppressor function for SIN3B that limits prostate adenocarcinoma progression, with potential implications for the use of SIN3B and its target genes as candidate diagnostic markers to distinguish indolent from aggressive disease. Cancer Res; 77(19); 5339–48. ©2017 AACR.