crc-22-0514-s15.pptx (715.79 kB)

Figure S10 from Immunologic Characterization and T cell Receptor Repertoires of Expanded Tumor-infiltrating Lymphocytes in Patients with Renal Cell Carcinoma

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posted on 2023-07-21, 17:40 authored by Moon Hee Lee, Jason Theodoropoulos, Jani Huuhtanen, Dipabarna Bhattacharya, Petrus Järvinen, Sara Tornberg, Harry Nísen, Tuomas Mirtti, Ilona Uski, Anita Kumari, Karita Peltonen, Arianna Draghi, Marco Donia, Anna Kreutzman, Satu Mustjoki

Figure S10 shows correlation of overlapping clonotypes between the tumor and pre-REP TILs.

Funding

Punainen Risti Veripalvelu (Finnish Red Cross Blood Service)

Academy of Finland (AKA)

Syöpäsäätiö (Cancerstiftelsen)

Sigrid Juséliuksen Säätiö (Sigrid Jusélius Stiftelse)

Signe ja Ane Gyllenbergin Säätiö (Signe and Ane Gyllenberg Foundation)

Relander Foundation (The Relander Foundation)

State funding university-level health research in Finland

History

ARTICLE ABSTRACT

TILs are a heterogenous group of immune cells that recognize and attack the tumor, thus are utilized in various clinical trials. In our study, we explored the TILs in patients with kidney cancer by expanding the TILs using a clinical-grade protocol, as well as observed their characteristics and ability to recognize the tumor using in-depth experimental and computational tools.

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Keywords

Genitourinary Cancers Renal cancer Tumor Microenvironment Immune cells and the microenvironment Immunology T cell exhaustion Gene Technologies High-throughput sequencing Computational Methods

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