Figure 5 from Identification of Causal Plasma Proteins in Hepatocellular Carcinoma via Two-Sample Mendelian Randomization and Integrative Transcriptomic‒Proteomic Analysis

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posted on 2025-03-12, 10:00 authored by Weihao Tang, Xiaoke Ma

Molecular docking visualization between target proteins and drugs. A–C, Molecular docking plot of ASS1 with arginine, aspartic acid, and citrulline, respectively. D–F, Molecular docking plot of KRT8 with ambroxol, diltiazem, and amikacin, respectively. G–I, Molecular docking plot of STOML2 with chlortetracycline, chlorzoxazone, and dirithromycin, respectively. ALA, alanine; ARG, arginine; ASN, asparagine; ASP, aspartic acid; GLN, glutamine; GLU, glutamic acid; GLY, glycine; ILE, isoleucine; LYS, lysine; MET, methionine; SER, serine; THR, threonine; TYR, tyrosine.

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ARTICLE ABSTRACT

In this study, we identified several causal proteins in HCC using UK Biobank Pharma Proteomics Project proteomic data via two-sample MR. We performed colocalization and sensitivity analyses, utilized single-cell RNA sequencing data for validation, and discovered potential drugs through molecular docking.