Figure 5 from Determining the N-Glycan and Collagen/Extracellular Matrix Protein Compositions in a Novel Outcome Cohort of Prostate Cancer Tissue Microarrays Using MALDI-MSI

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posted on 2024-11-27, 09:40 authored by Jordan P. Hartig, Kaitlyn Bejar, Lyndsay E.A. Young, Grace Grimsley, Jennifer R. Bethard, Dean A. Troyer, Javier Hernandez, Jennifer D. Wu, Joseph E. Ippolito, Lauren E. Ball, Jonathan A.L. Gelfond, Teresa L. Johnson-Pais, Anand S. Mehta, Robin J. Leach, Peggi M. Angel, Richard R. Drake

Collagen/ECM imaging data from TMAs comparing metastasis vs. no recurrence. A, Representative MALDI-MSI images of TMAs from metastasis (MET) category and no recurrence (NED) category. B, Segmentation analysis of 294 detected peptides. C, Volcano plot created from list of 294 detected peptides D, Heatmap of top 150 significantly different detected peptides. E, Box plot and ROC curve for 1179.5603 m/z. F, Box plot and ROC curve for 1426.6743 m/z. G, Box plot and ROC curve for 890.4250 m/z.

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ARTICLE ABSTRACT

Using matrix-assisted laser desorption/ionization mass spectrometry imaging techniques on a unique cohort of prostate cancer tissues, we highlighted several molecular characteristics of matrix that have potential to act as early predictors of prostate cancer metastasis.