Figure 4 from Identification of Causal Plasma Proteins in Hepatocellular Carcinoma via Two-Sample Mendelian Randomization and Integrative Transcriptomic‒Proteomic Analysis

Expression of the target genes in single-cell clusters of liver cancer tissue. A, Uniform Manifold Approximation and Projection dimension reduction plot of single cells from liver tissue of patients with liver cancer. B, Marker genes for each cell cluster. C, Feature plot showing the distribution of ASS1 across cell clusters. D, Violin plot showing the distribution of ASS1 across cell clusters. E, Feature plot showing the distribution of KRT8 across cell clusters. F, Violin plot showing the distribution of KRT8 across cell clusters. G, Feature plot showing the distribution of STOML2 across cell clusters. H, Violin plot showing the distribution of STOML2 across cell clusters. I, Feature plot showing the distribution of the liver cancer marker AFP across cell clusters. J, Gene differential expression of KRT8 in HPCs and malignant cells. K, IHC images of STOML2 in normal liver tissues and HCC (Left, patient ID: 1720, male, normal; right, patient ID: 889, male, HCC). CAFs, cancer-associated fibroblasts; TAMs, tumor-associated macrophages; TECs, tumor endothelial cells.