Figure 4 from Evaluating the Radiation Sensitivity Index and 12-Chemokine Gene Expression Signature for Clinical Use in a CLIA Laboratory

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posted on 2025-03-03, 08:40 authored by Anders E. Berglund, John Puskas, Sean J. Yoder, Andrew T. Smith, Douglas C. Marchion, Dahui Qin, James J. Mulé, Javier F. Torres-Roca, Steven A. Eschrich

Impact of surgery vs. biopsy sample on signature scores. A, Breast cancer specimens from tissue resection (surgery) and punch biopsy (biopsy) were compared. B, Head and neck cancer specimens from tissue resection (surgery) and punch biopsy (biopsy) were compared.

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ARTICLE ABSTRACT

The RSI and 12CK GES are two GESs that predict tumor radiation sensitivity or the presence of tertiary lymphoid structures in tumors, respectively. These GESs were assessed within the CLIA process for future clinical use. We established proficiency, reproducibility, and reliability characteristics for both signatures in a controlled setting, indicating these GESs are suitable for validation within future clinical trials.

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Keywords

Diagnostic Biomarkers Gene Expression Profiling Immunology Immunomodulation Radiation Oncology Radiation resistance

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CC BY