Figure 3 from Identification of Causal Plasma Proteins in Hepatocellular Carcinoma via Two-Sample Mendelian Randomization and Integrative Transcriptomic‒Proteomic Analysis

Results of colocalization and external validation. A, Colocalization results of 7 proteins identified by MR. Proteins were categorized based on H4 posterior probability in to 3 levels. (1) Level 1: ASS1 and KRT8 (PP.H4 ≥ 0.8); (2) level 2: STOML2 (0.5 < PP.H4 < 0.8); (3) level 3: B2M, FUOM, GABARAPL1, and ST8SIA1 (PP.H4 ≤ 0). B–D, Locus comparison plots of joint SNPs in terms of the association between blood plasma proteins and HCC in the respective pQTL and GWAS data of ASS1, KRT8, and STOML2. The left displays the −log₁₀P values for SNP associations with HCC outcomes along the x-axis and the −log₁₀P values for associations with blood plasma proteins from the UKB-PPP along the y-axis. The right displays genomic positions on the x-axis, with −log₁₀P values for the HCC outcome shown in the upper section and −log₁₀P values for blood plasma proteins shown in the lower section on the y-axis. E, Forest plot of external outcome validation of 3 proteins passed through colocalization, ASS1, KRT8, and STOML2. The error bar represents 95% CI of OR. GWAS, Genome-wide association study.