Figure 3 from Genomic Landscapes of Endometrioid and Mucinous Ovarian Cancers and Morphologically Similar Tumor Types

<p>WGS analyses of linked amplicons and rearrangements. <b>A,</b> Circos plots for linked amplicons for individual tumor samples with >100 structural variants. Circos plots depict copy number alterations as well as intra- and inter-chromosomal rearrangements. Segmented normalized estimates of read depth were used to identify candidate focal amplifications (teal) and focal deletions (red). Rearranged read pairs and split reads were used to identify inter- and intra-chromosomal rearrangements (blue). <b>B,</b> For linked amplicon graphs, nodes represent genes, node size represents the number of times the segment is represented in the genome, color indicates the chromosome location of the amplified segment, and edges denote segments that are connected in the rearranged cancer genome. Known driver genes indicated by triangles are often hubs in these networks, suggesting that amplification of these genes occurs early and can be connected to many of the other amplicons. <b>C,</b> Reads aligned to the fusion junction of two representative rearrangements. Split reads that span the fusion junction are shown in black, whereas read pairs that reside on either side of the junction are shown in green and blue, providing additional evidence for specific rearrangements.</p>