Figure 3 from Determining the N-Glycan and Collagen/Extracellular Matrix Protein Compositions in a Novel Outcome Cohort of Prostate Cancer Tissue Microarrays Using MALDI-MSI

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posted on 2024-11-27, 09:40 authored by Jordan P. Hartig, Kaitlyn Bejar, Lyndsay E.A. Young, Grace Grimsley, Jennifer R. Bethard, Dean A. Troyer, Javier Hernandez, Jennifer D. Wu, Joseph E. Ippolito, Lauren E. Ball, Jonathan A.L. Gelfond, Teresa L. Johnson-Pais, Anand S. Mehta, Robin J. Leach, Peggi M. Angel, Richard R. Drake

Statistical analysis of detected N-glycans in each category of TMA. A, PCA score plot of all 152 N-glycans. B, PLS-DA plot and corresponding importance feature plot. C,t test plot of NED vs. MET with structures shown for the top 10 most significant peaks. D, Pattern search graph showing the top 25 peaks correlated with 2905.0368 (Hex8dHex1HexNAc7), m/z values of N-glycans with at least one or more fucose shown in red boxes. VIP, variable importance in projection.

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ARTICLE ABSTRACT

Using matrix-assisted laser desorption/ionization mass spectrometry imaging techniques on a unique cohort of prostate cancer tissues, we highlighted several molecular characteristics of matrix that have potential to act as early predictors of prostate cancer metastasis.