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Figure 3 from A Comparative Study of Neuroendocrine Heterogeneity in Small Cell Lung Cancer and Neuroblastoma

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posted on 2023-08-01, 08:42 authored by Ling Cai, Ralph J. DeBerardinis, Yang Xie, John D. Minna, Guanghua Xiao

NE score is not associated with overall survival in SCLC or neuroblastoma. A, Survival association analysis for SCLC based on 79 patients from the George_2015 study. NE score is not significantly associated with overall survival in univariate Cox regression or a multivariate model controlling for sex and TNM stage. B, Meta-analysis for neuroblastoma based on seven studies and 1,531 patients. The result is also not statistically significant although significant results could be observed for individual studies, the trend was different. C, NE scores are not significantly altered in neuroblastoma relapsed samples. Paired samples from the same patients in two independent studies were compared.

Funding

American Cancer Society (ACS)

National Institute of General Medical Sciences (NIGMS)

United States Department of Health and Human Services

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National Institute of Dental and Craniofacial Research (NIDCR)

National Cancer Institute (NCI)

United States Department of Health and Human Services

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National Institute of Allergy and Infectious Diseases (NIAID)

United States Department of Health and Human Services

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Howard Hughes Medical Institute (HHMI)

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ARTICLE ABSTRACT

Lineage plasticity has long been documented in both small cell lung cancer (SCLC) and neuroblastoma, two clinically distinct neuroendocrine (NE) cancers. In this study, we quantified the NE features of cancer as NE scores and performed a systematic comparison of SCLC and neuroblastoma. We found neuroblastoma and SCLC cell lines have highly similar molecular profiles and shared therapeutic sensitivity. In addition, NE heterogeneity was observed at both the inter- and intra-cell line levels. Surprisingly, we did not find a significant association between NE scores and overall survival in SCLC or neuroblastoma. We described many shared and unique NE score‚Äďassociated features between SCLC and neuroblastoma, including dysregulation of Myc oncogenes, alterations in protein expression, metabolism, drug resistance, and selective gene dependencies. Our work establishes a reference for molecular changes and vulnerabilities associated with NE to non-NE transdifferentiation through mutual validation of SCLC and neuroblastoma samples.

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