Figure 2 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
posted on 2025-02-04, 09:40authored byElizabeth S. McDonald, Tien-Chi Pan, Dhruv K. Pant, Melissa A. Troester, Andrew V. Kossenkov, David A. Mankoff, Robert H. Mach, Lewis A. Chodosh
PGRMC1 is associated with early breast cancer relapse in a proliferation-dependent manner. Effect size estimates were aggregated across datasets by meta-analysis to determine the risk of relapse within 5 years from all cancers. A, Association of PGRMC1 with early breast cancer relapse. B, Association of PGRMC1 with early breast cancer relapse within the basal subtype. C, Association of PGRMC1 with early relapse adjusted for estimated proliferation. JRH, John Radcliffe Hospital.
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ARTICLE ABSTRACT
This first large-scale analysis of the putative ternary complex responsible for rapid low-density lipoprotein internalization in breast cancer reveals a link between component expression and recurrence, with prognostic implications for identifying patients needing supplemental posttreatment surveillance and/or additional therapeutic approaches.