Figure 2 from Identification of Causal Plasma Proteins in Hepatocellular Carcinoma via Two-Sample Mendelian Randomization and Integrative Transcriptomic‒Proteomic Analysis

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posted on 2025-03-12, 10:00 authored by Weihao Tang, Xiaoke Ma

Results of MR analysis. A, Volcanic plot of MR results in the European population. Proteins with labels demonstrate significance (P value < 8.66e−6). ns., no statistical significance; sig., statistical significance. B, Forest plot of MR results of 7 proteome-wide identified proteins from European population GWAS. The error bar represents 95% CI of OR. IV.number, the number of SNP instrumental variables.

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ARTICLE ABSTRACT

In this study, we identified several causal proteins in HCC using UK Biobank Pharma Proteomics Project proteomic data via two-sample MR. We performed colocalization and sensitivity analyses, utilized single-cell RNA sequencing data for validation, and discovered potential drugs through molecular docking.