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Figure 2 from Determining the N-Glycan and Collagen/Extracellular Matrix Protein Compositions in a Novel Outcome Cohort of Prostate Cancer Tissue Microarrays Using MALDI-MSI

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posted on 2024-11-27, 09:40 authored by Jordan P. Hartig, Kaitlyn Bejar, Lyndsay E.A. Young, Grace Grimsley, Jennifer R. Bethard, Dean A. Troyer, Javier Hernandez, Jennifer D. Wu, Joseph E. Ippolito, Lauren E. Ball, Jonathan A.L. Gelfond, Teresa L. Johnson-Pais, Anand S. Mehta, Robin J. Leach, Peggi M. Angel, Richard R. Drake

Glycan imaging data from TMA comparing metastasis vs. no recurrence. A, MALDI-MSI images of TMAs from metastasis (MET) category and no recurrence (NED) category. N-glycan images representative of differentiating expression of select N-glycan categories, followed by segmentation analysis of 152 detected N-glycans. B–I, Box plot and ROC curves for each category of N-glycan detected within each group of TMAs. t test results shown on each boxplot.

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ARTICLE ABSTRACT

Using matrix-assisted laser desorption/ionization mass spectrometry imaging techniques on a unique cohort of prostate cancer tissues, we highlighted several molecular characteristics of matrix that have potential to act as early predictors of prostate cancer metastasis.

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