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Figure 1 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence

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posted on 2025-02-04, 09:40 authored by Elizabeth S. McDonald, Tien-Chi Pan, Dhruv K. Pant, Melissa A. Troester, Andrew V. Kossenkov, David A. Mankoff, Robert H. Mach, Lewis A. Chodosh

A, PGRMC1 is overexpressed in human breast cancers of the basal subtype using PAM50. TMEM97 has the highest expression in luminal B tumors. B, PGRMC1 is overexpressed in hormone receptor–negative cancers. LDLR expression is highest in ER−/HER2+. TMEM97 has the highest expression in ER+/HER2+ tumors. C, PGRMC1 is overexpressed in smaller higher-grade tumors. LDLR and TMEM97 expression is highest in higher-grade tumors.

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ARTICLE ABSTRACT

This first large-scale analysis of the putative ternary complex responsible for rapid low-density lipoprotein internalization in breast cancer reveals a link between component expression and recurrence, with prognostic implications for identifying patients needing supplemental posttreatment surveillance and/or additional therapeutic approaches.

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