Figure 1 from Identification of Causal Plasma Proteins in Hepatocellular Carcinoma via Two-Sample Mendelian Randomization and Integrative Transcriptomic‒Proteomic Analysis

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posted on 2025-03-12, 10:00 authored by Weihao Tang, Xiaoke Ma

Flowchart of this study. PDB, Protein Data Bank; PP.H4.abf, H4 posterior probability.

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ARTICLE ABSTRACT

In this study, we identified several causal proteins in HCC using UK Biobank Pharma Proteomics Project proteomic data via two-sample MR. We performed colocalization and sensitivity analyses, utilized single-cell RNA sequencing data for validation, and discovered potential drugs through molecular docking.