FIGURE 8 from Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

NLRP3 inhibition increases gemcitabine efficacy. A, Tumor volume and weight in mice treated with vehicle (PBS), gemcitabine (GEM), OLT1177 (OLT), and GEM+OLT (n = 8/group). B, Flow cytometry analysis of Ki67 expression in CD45⁻ cells from the primary tumors obtained in A (n = 8/group). C, Viability of human PDAC organoids after 72 hours of culture in presence of gemcitabine (GEM) or OLT1177 (OLT; n = 3). D, Representative images of organoids from C. E, NLRP3 expression in primary tumors obtained in A (n = 3/group). Data expressed as mean ± SEM; ****, P < 0.0001; ***, P < 0.001; **, P < 0.01; *, P < 0.05.