FIGURE 6 from Tumor-infiltrating Leukocyte Profiling Defines Three Immune Subtypes of NSCLC with Distinct Signaling Pathways and Genetic Alterations

Characteristics of genomic alterations as a function of immune subtype. Numbers of cases analyzed using WES were LUAD (n = 69; Cold, n = 13; Myeloid, n = 31; CD8, n = 25), and LUSQ (n = 45; Cold, n = 11; Myeloid, n = 19; CD8, n = 15). Number of cases analyzed using RNA-seq for fusion genes are the same as described in Fig. 4. A–F, Characteristics of gene alterations. Number of patients are indicated in each column. Mutations of EGFR, TP53, KRAS, STK11, and RB1 in LUAD (A) and LUSQ (B) were analyzed using WES. ALK and ROS1 fusion genes in LUAD (C) and LUSQ (D) were analyzed with RNA-seq. Amplification or loss of MET and TERT in LUAD (E) and LUSQ (F) were analyzed using WES. Differences in gene alterations for immune subtypes in LUAD (G) and LUSQ (H) plotted as P values determined using Fisher exact test w. In the dot plots, red circles indicate P ≤ 0.05 and the filled red circle indicates Holm-adjusted P ≤ 0.2.