American Association for Cancer Research
Browse
crc-23-0138_fig6.png (641.32 kB)

FIGURE 6 from Serum Free Fatty Acid Changes Caused by High Expression of Stearoyl-CoA Desaturase 1 in Tumor Tissues Are Early Diagnostic Markers for Ovarian Cancer

Download (641.32 kB)
figure
posted on 2023-09-13, 14:20 authored by Kanoko Katoh, Yuki Katoh, Akiko Kubo, Miho Iida, Yuji Ikeda, Takashi Iwata, Hiroshi Nishio, Masaki Sugawara, Daiki Kato, Makoto Suematsu, Shuichi Hirai, Kei Kawana

Development of the stage I/II ovarian cancer detection model using serum FFAs levels. Diagnostic performance of the diagnostic index using FA18:1 and FA20:0 in the discovery (A) and validation (B) sets. Left: Comparison between healthy donor (HD) and patients with stage I/II ovarian cancer (Ov Pt). Right: ROC analysis. Threshold was set by calculating Youden index by ROC analysis using the discovery set. C, ROC analysis with cross-validation method applied to the complete dataset. D, Diagnostic performance of diagnostic index using CA125 on the discovery (left) and validation (right) sets. E, Test performance of DI (CA125) and DI (FA18:1, FA20:0) combination. Left: Patients with stage I/II ovarian cancer (n = 30) were diagnosed using DI (CA125) values. Black dots indicate true positive and red (clear cell), blue (serous), green (mucinous), and white (others) dots indicate false negative. Right: Patients with a false negative diagnosis by DI (CA125; n = 10) were successfully diagnosed using DI (FA18:1, FA20:0). ****, P < 0.0001.

Funding

Ministry of Education, Culture, Sports, Science and Technology (MEXT)

Takeda Science Foundation (TSF)

The Seiichi Imai Memorial Foundation

The Japan Society of Gynecologic Oncology

Nihon University

MEXT | JST | Moonshot Research and Development Program (Moonshot)

MEXT | JST | Exploratory Research for Advanced Technology (ERATO)

Human Biology Microbiome Quantum Research Center (WPI-Bio2Q)

History

ARTICLE ABSTRACT

Measurement of serum FFA levels by changes in the expression of fatty acid metabolizing enzymes in tumor tissue would allow early detection of ovarian cancer. In particular, the SCD1-associated FFAs, oleic and arachidic acid, would be powerful new screening tools for early-stage ovarian cancer.