FIGURE 6 from Serum Free Fatty Acid Changes Caused by High Expression of Stearoyl-CoA Desaturase 1 in Tumor Tissues Are Early Diagnostic Markers for Ovarian Cancer

Development of the stage I/II ovarian cancer detection model using serum FFAs levels. Diagnostic performance of the diagnostic index using FA18:1 and FA20:0 in the discovery (A) and validation (B) sets. Left: Comparison between healthy donor (HD) and patients with stage I/II ovarian cancer (Ov Pt). Right: ROC analysis. Threshold was set by calculating Youden index by ROC analysis using the discovery set. C, ROC analysis with cross-validation method applied to the complete dataset. D, Diagnostic performance of diagnostic index using CA125 on the discovery (left) and validation (right) sets. E, Test performance of DI (CA125) and DI (FA18:1, FA20:0) combination. Left: Patients with stage I/II ovarian cancer (n = 30) were diagnosed using DI (CA125) values. Black dots indicate true positive and red (clear cell), blue (serous), green (mucinous), and white (others) dots indicate false negative. Right: Patients with a false negative diagnosis by DI (CA125; n = 10) were successfully diagnosed using DI (FA18:1, FA20:0). ****, P < 0.0001.