crc-23-0044_fig6.png (217.39 kB)
FIGURE 6 from Proteogenomic Approaches for the Identification of NF1/Neurofibromin-depleted Estrogen Receptor–positive Breast Cancers for Targeted Treatment
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posted on 2023-07-26, 14:20 authored by Beom-Jun Kim, Ze-Yi Zheng, Jonathan T. Lei, Matthew V. Holt, Anran Chen, Jianheng Peng, Diana Fandino, Purba Singh, Hilda Kennedy, Yongchao Dou, María del Rosario Chica-Parrado, Emmanuel Bikorimana, Dan Ye, Yunguan Wang, Ariella B. Hanker, Nada Mohamed, Susan G. Hilsenbeck, Bora Lim, Jaya Ruth Asirvatham, Arun Sreekumar, Bing Zhang, George Miles, Meenakshi Anurag, Matthew J. Ellis, Eric C. ChangAssess the impact of NF1 protein levels on treatment responses in patient tumors. A, NF1 protein levels quantified by KIPA SureQuant (normalized by TIC) in each of the biopsy (orange circles) from a given POL patient were plotted and median is marked by a solid blue line. Blue and red dotted lines mark 75% and 25% quartile, respectively. The latter corresponds to 0.6 fmol/TIC. B, Tumors stratified by the 0.6 fmol/TIC cutoff were defined as NF1-high and NF1-low and their Ki67 levels pre-and post-letrozole treatment were plotted. P values were determined by paired t test.
