- No file added yet -

FIGURE 4 from Integrative Metatranscriptomic Analysis Reveals Disease-specific Microbiome–host Interactions in Oral Squamous Cell Carcinoma

figure

posted on 2023-05-08, 14:20 authored by Vinay Jain, Divyashri Baraniya, Doaa E. El-Hadedy, Tsute Chen, Michael Slifker, Fadhl Alakwaa, Kathy Q. Cai, Kumaraswamy N. Chitrala, Christopher Fundakowski, Nezar N. Al-Hebshi

Differentially abundant microbial features. Taxonomic and functional profiles obtained with HUMAnN 3.0 were CLR transformed and differential abundance analysis was performed with MaAsLin2 setting FDR cutoff to 0.05. A, Bar plots of the top differentially abundant genera in the tumor versus HC and adjacent normal versus HC contrasts. B, A heatmap showing clustering of samples based on top differentially abundant enzyme classes. The plots were created with ggplot2 and pheatmap R packages.

Funding

HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR)

Dr. Cary. R. Klimen Oral Health Sciences Research Program Fund

History

ARTICLE ABSTRACT

Studies have shown that a distinct microbiome is associated with OSCC, but how the microbiome functions within the tumor interacts with the host cells remains unclear. By simultaneously characterizing the microbial and host transcriptomes in OSCC and control tissues, the study provides novel insights into microbiome-host interactions in OSCC which can be validated in future mechanistic studies.