American Association for Cancer Research
crc-22-0463_fig4.png (693.55 kB)

FIGURE 4 from Immunologic Assessment of Tumors from a Race-matched Military Cohort Identifies Mast Cell Depletion as a Marker of Prostate Cancer Progression

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posted on 2023-08-01, 14:20 authored by Cara C. Schafer, Jiji Jiang, Sally Elsamanoudi, Darryl Nousome, Denise Y. Young, Yingjie Song, Isabell A. Sesterhenn, Gregory T. Chesnut, Shyh-Han Tan

Significant relative cell type scores for clinicopathologic variables. Relative cell type scores that demonstrated significance for GG (A), Gleason sum (B), metastasis (C), age at diagnosis group (D), and PSA (E) at diagnosis group are shown. Mann–Whitney U test (A, C) or Kruskal–Wallis test followed by Dunn multiple comparisons post-hoc test (B, D, E) were used to determine significance, as indicated by listed P values below 0.05. Each dot represents a patient score, and error bars correspond to mean ± SD.


DOD | USA | MEDCOM | CDMRP | DOD Prostate Cancer Research Program (PCRP)

DOD | Uniformed Services University of the Health Sciences (USU)



Our findings demonstrate that there are immune-related genes and pathways that differ by race. Impaired intratumoral cellular immune composition, especially for TIL-normalized mast cells, may be vital in predicting and contributing to prostate cancer disease progression.