crc-22-0443_fig4.png (416.21 kB)

FIGURE 4 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma

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posted on 2023-05-22, 14:20 authored by Ritu Chaudhary, Robbert J.C. Slebos, Leenil C. Noel, Feifei Song, Maria I. Poole, Dirk S. Hoening, Juan C. Hernandez-Prera, Jose R. Conejo-Garcia, Jose A. Guevara-Patino, Xuefeng Wang, Mengyu Xie, Aik Choon Tan, Christine H. Chung

Hypoxia subgroup has an enrichment of EGFR pathway. Pearson correlation coefficient for the TIMEx scores for the EGFR pathway and the Hypoxia gene signature among the TCGA (A), CPTAC (B), and Moffitt (C) HNSCC datasets. Expression distribution of EGFR RNA (D), protein (E), and phosphoprotein (F) levels among the three subgroups in the CPTAC HNSCC cohort.

Funding

HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR)

HHS | NIH | National Cancer Institute (NCI)

James and Esther King Biomedical Research Grant

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ARTICLE ABSTRACT

While the hypoxic and immunosuppressive TME of HNSCC has been well described, comprehensive evaluation of the immune cell components and signaling pathways contributing to immunotherapy resistance has been poorly characterized. We further identified additional molecular determinants and potential therapeutic targets of the hypoxic TME to fully leverage currently available targeted therapies that can be administered with immunotherapy.

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Keywords

Tumor Microenvironment Immune cells and the microenvironment Head, Neck & Oral Cancers Translational Research Precision Medicine Immunotherapy Combination immunotherapy Biological Agents & Therapies Antireceptors

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