figure posted on 2023-05-22, 14:20 authored by Ritu Chaudhary, Robbert J.C. Slebos, Leenil C. Noel, Feifei Song, Maria I. Poole, Dirk S. Hoening, Juan C. Hernandez-Prera, Jose R. Conejo-Garcia, Jose A. Guevara-Patino, Xuefeng Wang, Mengyu Xie, Aik Choon Tan, Christine H. Chung
Hypoxia subgroup has an enrichment of EGFR pathway. Pearson correlation coefficient for the TIMEx scores for the EGFR pathway and the Hypoxia gene signature among the TCGA (A), CPTAC (B), and Moffitt (C) HNSCC datasets. Expression distribution of EGFR RNA (D), protein (E), and phosphoprotein (F) levels among the three subgroups in the CPTAC HNSCC cohort.
HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR)
HHS | NIH | National Cancer Institute (NCI)
James and Esther King Biomedical Research Grant
ARTICLE ABSTRACTWhile the hypoxic and immunosuppressive TME of HNSCC has been well described, comprehensive evaluation of the immune cell components and signaling pathways contributing to immunotherapy resistance has been poorly characterized. We further identified additional molecular determinants and potential therapeutic targets of the hypoxic TME to fully leverage currently available targeted therapies that can be administered with immunotherapy.