FIGURE 3 from Effects and Eradication of Mycoplasma Contamination on Patient-derived Colorectal Cancer Organoid Cultures

Mycoplasma contamination can change organoid drug sensitivity. A, Dose–response curves for four sets of Mycoplasm-positive and -negative lines for three drugs: oxaliplatin, SN38, and 5-FU. *, P < 0.05 (Mann–Whitney). B, High-throughput screens for three sets of Mycoplasm-positive and -negative organoid lines. Percent killing for each drug is indicated by color, with red being the highest percent killing and blue being the lowest. C, Difference in percent killing in high-throughput screen between Mycoplasm-negative and -positive organoid lines.