American Association for Cancer Research
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FIGURE 3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

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posted on 2023-06-06, 14:20 authored by John B. Finlay, Ralph Abi Hachem, David W. Jang, Nosayaba Osazuwa-Peters, Bradley J. Goldstein

Patterns of gene expression in the normal differentiating OE. A, Trajectory UMAP depicting differentiation states across pseudotime, in seven normal olfactory mucosa biopsies scRNA-seq from Durante and colleagues, 2020 and Oliva and colleagues, 2021 (13, 24). B, Heat map showing canonical cell type–specific markers for selected OE cell stages. C, Schematic showing that the core PRC2 protein complex can combine with either EPOP+MTF2 to form PRC2.1 or with JARID2+AEBP2 to form PRC2.2. D, Heat map showing PRC2 gene expression (and IDH2). (HBC: horizontal basal cell; GBC: globose basal cell; INP: immediate neuronal precursor; iOSN: immature olfactory sensory neuron; mOSN: mature olfactory sensory neuron; PRC2: Polycomb repressive complex 2).


HHS | National Institutes of Health (NIH)



Our analyses provide a basis for additional research on olfactory neuroblastoma management, as well as identification of potential new prognostic markers.